NUDT15 Haplotypes and Diplotypes Predict Thiopurine-Induced Leukopenia and the Influence of Prolonged Exposure to Azathioprine on Hematologic Indices in Patients with Inflammatory Bowel Diseases
Table 5
Univariate and multivariate analyses of AZA-induced leukopenia.
Characteristics
With leukopenia
Without leukopenia
Univariate analysis
Multivariate analysis
OR
95% CI
OR
95% CI
No. of subjects, n
21
59
Female number (%)
7 (30)
18 (30.5)
0.81
Age (years), M(R)
32 (20–58)
29 (17–78)
0.491
Group of age (yr)
0.39
17–40
14
45
>40
7
14
NUDT15 (%)
c.415C > T
12 (57.1)
8 (13.6)
7.5×10−5
8.5
2.72–26.61
0.02
4.90
1.28–18.69
c.36_37insGGAGTC
7 (30)
4 (6.8)
0.006
6.88
1.76–26.82
0.193
2.39
0.87–16.21
c.52G > A
1 (4.8)
0 (0)
0.262
3.95
2.71–5.77
Type of disease, n
0.669
CD
20
53
UC
1
6
AZA final dosage (mg·kg−1·d−1), mean ± SD
1.23 ± 0.52
1.30 ± 0.44
0.549
AZA duration (wk), M(R)
48 (2–336)
48 (1–228)
0.248
Concomitant therapy, n
13
40
0.624
5-ASA
2
15
0.213
Steroids
8
27
0.459
IFX
2
5
1
Thalidomide
3
5
0.426
The values in bold in the table are less than 0.05.
