Dihydromyricetin Alleviates Nonalcoholic Fatty Liver Disease and Its Associated Metabolic Syndrome by Inhibiting Endoplasmic Reticulum Stress in LDLR^−/− Mice Fed with a High-Fat and High-Fructose Diet

Figure 2

Diet-induced insulin resistance was alleviated in the DHM-treated LDLR^−/− mice: (a) plasma glucose levels before and during the DHM challenge and ND or HFD feeding, (b) plasma insulin levels after 12 weeks of ND or HFD feeding, (c) glucose tolerance test (GTT) after 10 weeks of ND or HFD feeding, (d) area under the curve shown in figure (C), (e) the insulin tolerance test (ITT) after 11 weeks of HFD, and (f) area under the curve of figure (E). n = 8 per group; ^#compared with the normal control group (ND); &, compared with the control group (HFD); ^#/& and ^##/&&.

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