Dihydromyricetin Alleviates Nonalcoholic Fatty Liver Disease and Its Associated Metabolic Syndrome by Inhibiting Endoplasmic Reticulum Stress in LDLR<sup>−/−</sup> Mice Fed with a High-Fat and High-Fructose Diet

<div>Diet-induced fat deposition was alleviated in the liver of the DHM-treated LDLR<sup>−/−</sup> mice: (a) liver weight, (b, c) total liver triglyceride and cholesterol content; <i>n</i> = 8 per group, (d) H&amp;E (top) and Oil Red O (bottom) staining of the liver; bar = 100 <i>μ</i>m, (e) western blot analysis of p-Akt (Ser473) and total Akt in the liver (<i>n</i> = 4 per group),and (f) mRNA expression of genes related to triglyceride and cholesterol metabolism in the liver; <i>n</i> = 6 per group; <sup>#</sup>compared with the normal control group (ND); <sup>&amp;</sup>compared with the control group (HFD); <sup>#/&amp;</sup><span class="nowrap"><svg height="9.2729pt" id="M10" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 49.1898 9.2729" width="49.1898pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 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602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,42.715,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z"></path></g></svg>,</span> <sup>##/&amp;&amp;</sup><span class="nowrap"><svg height="9.2729pt" id="M11" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 47.0146 9.2729" width="47.0146pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 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Journal of Clinical Pharmacy and Therapeutics

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Figure 4

Figure 4: Dihydromyricetin Alleviates Nonalcoholic Fatty Liver Disease and Its Associated Metabolic Syndrome by Inhibiting Endoplasmic Reticulum Stress in LDLR<sup>−/−</sup> Mice Fed with a High-Fat and High-Fructose Diet 

Figure 4 | Dihydromyricetin Alleviates Nonalcoholic Fatty Liver Disease and Its Associated Metabolic Syndrome by Inhibiting Endoplasmic Reticulum Stress in LDLR−/− Mice Fed with a High-Fat and High-Fructose Diet 