Journal of Clinical Pharmacy and Therapeutics

Research Article

Efficacy and Safety of the Intraoperative Application of Mitomycin in Glaucoma Patients with Trabeculectomy: A Systematic Review and Meta-Analysis

Table 1

Basic characteristic of the new RCTs in this systematic review of the efficacy and safety of MMC in trabeculectomy.
Authors (years)Study typesPatientsType of surgeryTotal numbersNumber of eyesMalesAgeNumber in the control groupsNumber in the intervention groupsControl groupsIntervention groupsMMC dosingFollow-uptime
Huang 2012RCTGlaucoma patientsTrabeculectomy576136543130Without MMCMMCIntraoperative cotton padsSix months
Liu Lijing 2015RCTGlaucoma patientsTrabeculectomy911213747.53130Without MMCMMCCotton pads soaked in 0.2 mg/mL mitomycin C were placed under the scleral flap and conjunctival flap for 3 min and rinsed with normal saline for 5 min12 months
Gu Quan 2015RCTGlaucoma patientsTrabeculectomy10310341535152Without MMCMMCA cotton pad impregnated with 0.2 g/L mitomycin C was placed between the Tenon’s capsule and the scleral valve bed for 5 minSix to 12 months
Li Qian 2012RCTRefractory glaucoma patientsTrabeculectomy909843544850Without MMCMMC0.2% MMC cotton sheetFive to 12 months
Liu Shi 2014RCTPrimary glaucoma patientsTrabeculectomy57952159.143126Without MMCMMCPlace cotton pads soaked with 0.2 mg/mL MMC under the scleral flap and the conjunctival flap for 1 to 4 minFour to six months
Zhao Ruizhi 2012RCTGlaucoma patientsTrabeculectomy1201206655.56060Without MMCMMC0.25–0.67 mg/mL mitomycin C cotton pad that was slightly larger than the size of the scleral flap was placed under the scleral flap and the surrounding conjunctiva for 2–5 min12 Mon
Liu Yadan 2010RCTGlaucoma patientsTrabeculectomy54542526–683227Without MMCMMCTake 0.2 mg/mL MMC from cotton piecesOne, six months
Andreanos 1997RCTPatients with uncontrolled glaucoma who had all had previous filtration surgeryStandard trabeculectomy46 2664.22422Without MMCMMCWith MMC 0.4 mg/mL for 2-3 min18 months
Cohen 1996RCTPatients with cataracts and glaucoma for combined surgeryStandard trabeculectomy72 2375.943536PlaceboMMCWith a perioperative sponge soaked with MMC 0.5 mg/mL for 2.5 min applied to the scleral incision12 months
Costa 1996RCTPatients with uncontrolled POAG or CACGStandard trabeculectomy28282267.011414PlaceboMMCWith MMC 0.2 mg/mL for 3 min24 months
Martini 1997RCTPatients with uncontrolled glaucomaStandard trabeculectomy48664265.53030Without MMCMMCWith MMC 0.1 mg/mL or with MMC 0.1 mg/mLOne year
Robin 1997RCTPatients with POAG, PACG, pigmentary and exfoliation glaucomaTrabeculectomy300     Without MMCMMCWith placebo, MMC 0.2 mg/mL for 2 or 4 min, or MMC 0.4 mg/mL for 2 minOne year
Szymanski 1997RCTPatients with POAGTrabeculectomy29 1447.8821PlaceboMMCWith MMC 0.2 mg/mL or 0.5 mg/mL 
Turacli 1996RCTPatients with POAG, closed-angle, and secondary glaucomaStandard trabeculectomy86 4857.72830Without MMCMMCWith MMC30 months
Wu 1996RCTPatients with uveitic, aphakic, neovascular, traumatic, and infantile glaucomaStandard trabeculectomy30402131.171921Without MMCMMCWith MMC 0.4 mg/mL for 5 minTen months