Effects of New Antiepileptic Drugs on Homocysteine in Epileptic Patients: A Systematic Review and Meta-Analysis

Table 3

Results of subgroup analyses on the age and counrty.

	I^2	WMD	95% CI
OXC	97.7	2.30	−1.11, 5.72	0.187
Country
East Middle	0%	0.43	(−1.13, 1.99)	0.54
China	58.9%	1.62	(−0.12, 3.36)	0.069
Europe	—	6.90	(6.66, 7.14)	≤0.001
Age
Children	—	0.95	(0.01, 1.89)	0.047
Adults	94.9%	2.61	(−1.08, 6.29)	0.165
LEV	77%	1.81	1.03–2.18	≤0.001
Country
East Middle	81.9%	1.77	0.01–3.54	0.048
China	6.2%	0.87	−0.09–1.83	0.077
Europe	—	2.0	1.82–2.18	≤0.001
Age
Children	89.4%	2.318	0.658–3.977	≤0.001
Adults	57.3%	1.179	−0.162–2.519	0.071
LTG	86.3%	1.136	−0.209–2.482	≤0.001
Country
East Middle	—	3.900	2.178–5.622	≤0.001
China	0%	−0.087	−0.915–0.742	0.838
Europe	—	2.000	1.827–2.173	≤0.001
Age
Children	87.6%	0.54	−0.961–2.042	0.481
Adults	—	3.900	2.178–5.622	≤0.001
TPM	98.3%	6.922	0.788–13.055	0.027
Country
East Middle	—	3.740	2.147–5.333	≤0.001
Europe	—	10.000	9.754–10.246	≤0.001

Note. OXC, oxcarbazepine. LEV, levetiracetam. LTG, lamotrigine. TPM, topiramate.