Journal of Clinical Pharmacy and Therapeutics

Research Article

SLC2A9 Gene Polymorphism Is Associated with Elevated Serum Uric Acid Caused by Pyrazinamide

Table 3

Comparison of the gene distributions between groups.


SNPs		Low-risk group (n = 60)		High-risk group (n = 83)		OR (95% CI)	value
SNPs		n	%	n	%	OR (95% CI)	value

SLC2A9 rs1014290
Allele	A	62	51.7	120	72.3	1.000 (ref.)	—
Allele	G	58	48.3	46	27.7	0.410 (0.250–0.671)
Codominant model	AA	9	15.0	46	55.4	1.000 (ref.)	—
	GA	44	73.3	28	33.7	0.125 (0.053–0.293)
	GG	7	11.7	9	10.8	0.252 (0.074–0.851)
Dominant model	AA	9	15.0	46	55.4	1.000 (ref.)	—
Dominant model	GA + GG	51	85.0	37	44.6	0.142 (0.062–0.326)
Recessive model	AA + GA	53	88.3	74	89.2	1.000 (ref.)	—
Recessive model	GG	7	11.7	9	10.8	0.921 (0.323–2.628)	0.878

SLC2A9 rs11722228
Allele	C	91	75.8	109	65.7	1.000 (ref.)	—
Allele	T	29	24.2	57	34.3	1.641 (0.969–2.778)	0.064
Codominant model	CC	34	56.7	35	42.2	1.000 (ref.)	—
	CT	23	38.3	39	47.0	1.647 (0.819–3.313)	0.162
	TT	3	5.0	9	10.8	2.914 (0.726–11.692)	0.131
Dominant model	CC	34	56.7	35	42.2	1.000 (ref.)	—
Dominant model	CT + TT	6	43.3	48	57.8	1.793 (0.917–3.509)	0.087
Recessive model	CC + CT	57	95.0	74	89.2	1.000 (ref.)	—
Recessive model	TT	3	5.0	9	10.8	2.311 (0.598–8.927)	0.214

SLC2A9 rs13129697
Allele	T	71	59.2	120	73.9	1.000 (ref.)	—
Allele	G	49	40.8	46	26.1	0.531 (0.312–0.842)
Codominant model	TT	11	18.3	37	44.6	1.000 (ref.)	—
Codominant model	TG	49	81.7	46	55.4	0.279 (0.127–0.611)

SLC22A12 rs3825016
Allele	C	91	75.8	128	77.1	1.000 (ref.)	—
Allele	T	29	24.2	38	22.9	0.932 (0.536–1.619)	0.802
Codominant model	CC	32	53.3	47	56.6	1.000 (ref.)	—
	CT	27	45.0	34	41.0	0.857 (0.436–1.686)	0.655
	TT	1	1.7	2	2.4	1.362 (0.118–15.656)	0.804
Dominant model	CC	32	53.3	47	56.6	1.000 (ref.)	—
Dominant model	CT + TT	28	46.7	36	43.4	0.875 (0.449–1.707)	0.696
Recessive model	CC + CT	59	98.3	81	97.6	1.000 (ref.)	—
Recessive model	TT	1	1.7	2	2.4	1.457 (0.129–16.445)	0.760

SLC22A12 rs475688
Allele	C	55	45.8	67	40.4	1.000 (ref.)	—
Allele	T	65	54.2	99	59.6	1.250 (0.778–2.009)	0.356
Codominant model	CC	11	18.3	10	12.0	1.000 (ref.)	—
	CT	33	55.0	47	56.6	1.567 (0.597–4.113)	0.362
	TT	16	26.7	26	31.3	1.141 (0.531–2.453)	0.736
Dominant model	CC	11	18.3	10	12.0	1.000 (ref.)	—
Dominant model	CT + TT	49	81.7	73	88.0	1.639 (0.647–4.152)	0.295
Recessive model	CC + CT	44	73.3	57	68.7	1.000 (ref.)	—
Recessive model	TT	16	26.7	26	31.3	1.254 (0.601–2.620)	0.546

SLC22A12 rs7929627
Allele	A	75	62.5	102	61.4	1.000 (ref.)	—
Allele	G	45	37.5	64	38.6	1.046 (0.645–1.697)	0.856
Codominant model	AA	21	35.0	37	44.6	1.000 (ref.)	—
	AG	33	55.0	28	33.7	0.482 (0.231–1.004)	0.051
	GG	6	10.0	18	21.7	1.703 (0.585–4.954)	0.329
Dominant model	AA	21	35.0	37	44.6	1.000 (ref.)	—
Dominant model	AG + GG	39	65.0	46	55.4	0.669 (0.338–1.328)	0.250
Recessive model	AA + AG	54	90.0	65	78.3	1.000 (ref.)	—
Recessive model	GG	6	10.0	18	21.7	2.492 (0.924–6.720)	0.065

SLC22A12 rs893006
Allele	C	91	75.8	128	77.1	1.000 (ref.)	—
Allele	A	29	24.2	38	22.9	0.932 (0.536–1.619)	0.802
Codominant model	CC	32	53.3	47	56.6	1.000 (ref.)	—
	CA	27	45.0	34	41.0	0.857 (0.436–1.686)	0.655
	AA	1	1.7	2	2.4	1.362 (0.118–15.656)	0.804
Dominant model	CC	32	53.3	47	56.6	1.000 (ref.)	—
Dominant model	CA + AA	28	46.7	36	43.4	0.875 (0.449–1.707)	0.696
Recessive model	CC + CA	59	98.3	81	97.6	1.000 (ref.)	—
Recessive model	AA	1	1.7	2	2.4	1.457 (0.129–16.445)	0.760

ABCG2 rs2054576
Allele	A	96	80.0	132	79.5	1.000 (ref.)	—
Allele	G	24	20.0	34	20.5	1.030 (0.574–1.849)	0.920
Codominant model	AA	37	61.7	54	65.1	1.000 (ref.)	—
	AG	22	36.7	24	28.9	0.747 (0.366–1.526)	0.424
	GG	1	1.7	5	6.0	3.426 (0.384–30.532)	0.317
Dominant model	AA	37	61.7	54	65.1	1.000 (ref.)	—
Dominant model	AG + GG	23	38.3	29	34.9	0.864 (0.434–1.720)	0.677
Recessive model	AA + AG	59	98.3	78	94.0	1.000 (ref.)	—
Recessive model	GG	1	1.7	5	6.0	3.782 (0.430–33.240)	0.200

ABCG2 rs2231142
Allele	G	91	75.8	117	70.5	1.000 (ref.)	—
Allele	T	29	24.2	49	29.5	1.314 (0.770–2.243)	0.316
Codominant model	GG	34	56.7	40	48.2	1.000 (ref.)	—
	TG	23	38.3	37	44.6	1.367 (0.684–2.734)	0.376
	TT	3	5.0	6	7.2	1.700 (0.395–7.315)	0.476
Dominant model	GG	34	56.7	40	48.2	1.000 (ref.)	—
Dominant model	GT + TT	26	43.3	43	51.8	1.406 (0.721–2.741)	0.317
Recessive model	GG + GT	67	95.7	77	92.8	1.000 (ref.)	—
Recessive model	TT	3	4.3	6	7.2	1.740 (0.419–7.229)	0.441

ABCG2 rs2728109
Allele	A	26	21.7	35	21.1	1.000 (ref.)	—
Allele	C	94	78.3	131	78.9	1.035 (0.584–1.835)	0.906
Codominant model	AA	1	1.7	7	8.4	1.000 (ref.)	—
	AC	24	40.0	21	25.3	0.125 (0.014–1.101)	0.061
	CC	35	58.3	55	66.3	0.224 (0.026–1.904)	0.171
Dominant model	AA	1	1.70	7	8.4	1.000 (ref.)	—
Dominant model	AC + CC	59	98.3	76	91.6	0.184 (0.022–1.537)	0.082
Recessive model	AA + AC	25	41.7	28	33.7	1.000 (ref.)	—
Recessive model	CC	35	58.3	55	66.3	1.403 (0.707–2.786)	0.332

ABCG2 rs3114018
Allele	A	46	38.3	64	38.6	1.000 (ref.)	—
Allele	C	74	61.7	102	61.4	0.991 (0.611–1.606)	0.970
Codominant model	AA	6	10.0	12	14.5	1.000 (ref.)	—
	AC	34	56.7	40	48.2	0.588 (0.199–1.735)	0.336
	CC	20	33.3	31	37.3	0.775 (0.250–2.399)	0.658
Dominant model	AA	6	10.0	12	14.5	1.000 (ref.)	—
Dominant model	AC + CC	54	90.0	71	85.5	0657 (0.232–1.864)	0.428
Recessive model	AA + AC	40	66.7	52	62.7	1.000 (ref.)	—
Recessive model	CC	20	33.3	31	37.3	1.192 (0.594–2.394)	0.621

CI, confidence interval; OR, odds ratio. The difference was statistically significant ().