Digestive Tract Cancer-Related Adverse Events Correlated with Proton Pump Inhibitors Use: A Pharmacovigilance Study of the FDA Adverse Event Reporting System

Table 1

HLTs and PTs according to MedDRA 24.0.

HLT subordinate to the HLGT “gastrointestinal neoplasms malignant and unspecified”
HLT		Abbreviations		HLT		Abbreviations
Gastric neoplasms malignant		GNM		Colorectal neoplasms malignant		CNM
Pancreatic neoplasms malignant		PNM		Anal canal neoplasms malignant		ACNM
Bile duct neoplasms malignant		BDNM		Gallbladder neoplasms malignant		GBNM
Small intestinal neoplasms malignant		SINM		Hepatic neoplasms malignant		HNM
Oesophageal neoplasms malignant		ONM
PT subordinate to the HLT “gastric neoplasms malignant”
PT	Adenocarcinoma gastric		Gastric cancer		Gastric cancer recurrent
	Gastric cancer stage 0		Gastric cancer stage I		Gastric cancer stage II
	Gastric cancer stage III		Gastric cancer stage IV		Gastric sarcoma
	Gastroesophageal cancer		Gastroesophageal cancer recurrent		HER2-positive gastric cancer
	Linitis plastica		Metastatic gastric cancer
PT subordinate to the HLT “bile duct neoplasms malignant”
PT	Bile duct adenocarcinoma		Bile duct adenosquamous carcinoma		Bile duct cancer
	Bile duct cancer recurrent		Bile duct cancer stage 0		Bile duct cancer stage I
	Bile duct cancer stage II		Bile duct cancer stage III		Bile duct cancer stage IV
	Bile duct squamous cell carcinoma		Biliary cancer metastatic		Cholangiocarcinoma
	Cholangiosarcoma

HLGT, high-level group term; HLTs, high-level terms; PTs, preferred terms.