Changes of the Types and Daily Costs of Topical Antiglaucoma Medications from 2006 to 2021 in China

Table 1

Types and daily costs of antiglaucoma medications in 2021.

Classifications	Trade name	Active ingredient (concentration)	Manufacturer	No. drops/bottle	Volume/bottle (mL)	Volume/drop (μL)	No. drops for both eyes per day	Price^aUS dollars^b	Cost/drop US dollars	No. days/bottle (both eyes)	Cost/day (both eyes) US dollars
Prostaglandin analogs	Xalatan	Latanoprost 0.005%	Pfizer, United States	88.3 ± 0.47	2.5	28.3 ± 0	2	26.76	0.30	44	0.61
	Ruidaxi	Latanoprost 0.005%	Taejun, Korea	79.7 ± 0.47	2.5	31.4 ± 0.5	2	15.51	0.19	39	0.39
	Telijie	Latanoprost 0.005%	Lunan Beite, China	76.7 ± 0.58	2.5	32.6 ± 0.5	2	18.95	0.25	38	0.49
	Jiankang	Latanoprost 0.005%	Huarun Zizhu, China	78.3 ± 1.15	2.5	32.0 ± 0	2	20.91	0.27	39	0.53
	Shengao	Latanoprost 0.005%	Chengdu Hengrui, China	76.3 ± 2.31	2.5	32.8 ± 0.5	2	16.24	0.21	38	0.43
	Travatan	Travoprost 0.004%	Alcon, United States	71.3 ± 1.25	2.5	35.0 ± 0.8	2	26.40	0.37	35	0.74
	Nuoming	Travoprost 0.004%	Hubei Yuanda, China	76.3 ± 4.04	2.5	32.8 ± 1.7	2	23.96	0.31	38	0.63
	Lumigan	Bimatoprost 0.03%	Allergan, United States	110.7 ± 0.47	3	27.1 ± 0	2	21.96	0.20	55	0.40
	Tafluprost	Tafluprost 0.0015%	Santen, Japan	89.0 ± 2.16	2.5	28.1 ± 0.8	2	11.73	0.13	44	0.26
	Tafluprost	Tafluprost 0.0015% (unit dose package: 0.3 ml × 30/box)	Santen, Japan	60.0 ± 0.00 (2 × 30)^c	9.0 (0.3 ml × 30)	150 ± 0	2	69.45	1.16	30	2.32
β-adrenergic blocker	Wujing	Timolol maleate 0.5%	Wuhan Wujing, China	116.33 ± 2.05	5	43.0 ± 0.8	4	3.39	0.03	29	0.12
	Tiantianming	Timolol maleate 0.25% (unit dose package: 0.4 ml × 15/box)	Hubei Yuanda, China	30 ± 0.00 (2 × 15)^c	6 (0.4 ml × 15)	200 ± 0	4	7.06	0.24	7	0.94
	Xiutong	Timolol maleate 0.5%	Guangdong Hongying, China	153.0 ± 15.56	5	32.7 ± 2.8	4	3.11	0.02	38	0.08
	Chengrui	Timolol maleate 0.5%	Shandong Bausch & Lomb Furuida, China	118.0 ± 0.82	5	42.4 ± 0.5	4	1.51	0.01	29	0.05
	Yuanheng	Timolol maleate 0.25%	Jiangsu Yuanheng, China	104.3 ± 2.08	5	48.0 ± 1.0	4	3.05	0.02	26	0.06
	Betoptic	Betaxolol hydrochloride 0.25%	Alcon, United States	227 ± 6.98	5	22.0 ± 0.8	4	5.60	0.03	56	0.10
	Mikelan	Carteolol hydrochloride 1%	Otsuka, China-Japan	124.33 ± 3.68	5	40.2 ± 1.2	4	2.80	0.02	31	0.09
	Mikelan	Carteolol hydrochloride 2%	Otsuka, China-Japan	122 ± 1.41	5	41.0 ± 0.5	4	3.46	0.03	30	0.11
	Mikelan	Carteolol hydrochloride 2% (unit dose package: 0.6 ml × 10/box)	Otsuka, China-Japan	20 ± 0.00 (2 × 10)^c	6 (0.6 ml × 10)	300 ± 0	4	12.55	0.63	5	2.51
Carbonic anhydrase inhibitor	Azopt	Brinzolamide 1%	Alcon, United States	150.7 ± 0.47	5	33.2 ± 0	4	9.66	0.06	37	0.26
α2-Adrenergic agonist	Alphagan	Brimonidine tartrate 0.2%	Allergan, United States	152 ± 3.56	5	32.9 ± 0.9	4	10.65	0.07	38	0.28
	Alphagan	Brimonidine tartrate 0.15%	Allergan, United States	114.7 ± 1.88	5	43.6 ± 0.9	4	11.23	0.10	28	0.39
	Zhuoneng	Brimonidine tartrate 0.2%	Nanjing Hengsheng, China	136.0 ± 2.65	5	36.8 ± 0.5	4	6.56	0.05	34	0.19
	Huonland	Brimonidine tartrate 0.2%	Beijing Huonland, China	158 ± 4.55	5	31.6 ± 1.2	4	6.56	0.04	39	0.16
Cholinergic	Zhenrui	Pilocarpine nitrate 2%	Shandong Bausch & Lomb Furuida, China	112.3 ± 0.94	5	44.5 ± 0.3	8	2.27	0.02	14	0.16
	Zezhu	Pilocarpine nitrate 0.5%	Anhui Shuangke, China	103 ± 1.41	5	48.5 ± 0.5	8	5.73	0.05	12	0.44
	Yongguang	Pilocarpine nitrate 1%	Yongguang, China	154.3 ± 0.47	5	32.4 ± 0	8	1.13	0.01	19	0.06
Fixed-dose combinations	Xalacom	Latanoprost 0.0025% and timolol maleate 0.272%	Pfizer, United States	88.7 ± 0.94	2.5	28.2 ± 0	2	29.73	0.34	44	0.67
	Duotrav	Travoprost 0.004% and timolol maleate 0.5%	Alcon, United states	84.7 ± 2.05	2.5	29.5 ± 0.5	2	28.93	0.34	42	0.68
	Ganfort	Bimatopros 0.03% and 0.5% timolol	Allergan, Ireland	105.3 ± 2.36	3	28.5 ± 0.5	2	23.41	0.22	52	0.45
	Azarga	Brinzolamide 1% and timolol 0.5%	Alcon, United states	149.3 ± 3.86	5	33.5 ± 0.9	4	6.43	0.04	37	0.17
	Simbrinza	Brinzolamide 1% and brimonidine tartrate 0.2%	Novartis, Switzerland	133 ± 1.63	5	37.6 ± 0.5	4	9.88	0.07	33	0.29

^aThe prices of different antiglaucoma drugs were originated from YAOZH database (https://www.yaozh.com) by the end of December 31, 2021. ^b1 US dollar = 6.3757CNY (by the end of December 31, 2021). ^cAccording to the instructions of the drugs with unit dose package, every single package can be used for two droplets. The volume/drop is calculated accordingly.