Changes of the Types and Daily Costs of Topical Antiglaucoma Medications from 2006 to 2021 in China

Table 2

Comparisons of the daily costs of the same antiglaucoma drugs between 2006 and 2021.

Trade name	Active ingredient (concentration)	Manufacturer (2021)	Price^a(2006) US dollars^b	Price (2021) US dollars^c	Cost/day^a(2006) US dollars^b	Cost/day (2021) US dollars^c	Change of cost/day (2021–2006)	Change rate of cost/day (2021–2006)
Alphagan	Brimonidine tartrate 0.2%	Allergan, United States	15.09	10.65	0.61	0.28	−0.33	−54%
Mikelan	Carteolol hydrochloride 2%	Otsuka, China-Japan	5.65	3.46	0.15	0.11	−0.04	−27%
Wujing	Timolol maleate 0.5%	Wuhan Wujing, China	0.89	3.39	0.03	0.12	+0.09	+300%
Chengrui	Timolol maleate 0.5%	Shandong Bausch & Lomb Furuida, China	2.17	1.51	0.08	0.05	−0.03	−38%
Betoptic	Betaxolol hydrochloride 0.25%	Alcon, United States	9.08	5.60	0.24	0.10	−0.14	−58%
Zhenrui	Pilocarpine nitrate 2%	Shandong Bausch & Lomb Furuida, China	4.24	2.27	0.28	0.16	−0.12	−43%
Azopt	Brinzolamide 1%	Alcon, United States	15.61	9.66	0.34	0.26	−0.08	−24%
Travatan	Travoprost 0.004%	Alcon, United States	46.75	26.41	0.77	0.74	−0.03	−4%
Lumigan	Bimatoprost 0.03%	Allergan, United States	31.06	21.97	0.46	0.40	−0.06	−13%
Xalatan	Latanoprost 0.005%	Pfizer, United States	53.03	26.76	0.91	0.61	−0.3	−33%
Mean ± SD			18.36 ± 18.86	11.17 ± 10.10	0.39 ± 0.30	0.28 ± 0.23
^d			<0.001		<0.001

^aThe prices of different antiglaucoma drugs and daily costs in 2006 were originated from the previous study (Gao Y, Wu L, Li A. Daily cost of glaucoma medications in China. J Glaucoma. 2007; 16(7):594–597.). ^b1 US dollar = 8.2889 CNY (2006). ^c1 US dollar = 6.3757 CNY (2021). ^d value was analyzed by pair t test.