|
| SOC | Preferred terms (PTs) | N | ROR (95% one-sided CI) | PRR (χ2) | IC (IC025) | EBGM (EBGM05) |
|
| Infections and infestations | COVID-19 | 1719 | 5.39 (5.14) | 5.28 (9105.87) | 2.38 (2.31) | 5.21 (5) |
| Urinary tract infection | 630 | 4.43 (4.09) | 4.4 (1108.22) | 2.12 (2.01) | 4.35 (4.07) |
| Pneumonia | 574 | 2.22 (2.05) | 2.21 (463.05) | 1.14 (1.02) | 2.2 (2.06) |
| Nasopharyngitis | 461 | 3.11 (2.84) | 3.1 (456.05) | 1.62 (1.49) | 3.08 (2.85) |
| Herpes zoster | 398 | 7.73 (7) | 7.69 (560.05) | 2.91 (2.77) | 7.53 (6.93) |
| Infection | 350 | 2.77 (2.49) | 2.76 (233.1) | 1.46 (1.31) | 2.75 (2.51) |
| Sinusitis | 343 | 4.01 (3.6) | 3.99 (308.91) | 1.98 (1.83) | 3.95 (3.62) |
| Influenza | 269 | 3.25 (2.89) | 3.25 (161.88) | 1.69 (1.52) | 3.22 (2.91) |
| Bronchitis | 174 | 3.29 (2.83) | 3.28 (68.35) | 1.7 (1.49) | 3.26 (2.87) |
| Upper respiratory tract infection | 144 | 4.33 (3.67) | 4.32 (57.17) | 2.1 (1.86) | 4.27 (3.72) |
| Localised infection | 131 | 5.93 (4.99) | 5.92 (55.35) | 2.54 (2.3) | 5.83 (5.05) |
| Diverticulitis | 121 | 5.2 (4.34) | 5.19 (44.56) | 2.36 (2.1) | 5.12 (4.41) |
| Ear infection | 100 | 4.51 (3.71) | 4.51 (28.28) | 2.16 (1.88) | 4.46 (3.78) |
| COVID-19 pneumonia | 98 | 3.95 (3.24) | 3.95 (25) | 1.97 (1.69) | 3.91 (3.31) |
| Cystitis | 98 | 3.69 (3.02) | 3.69 (23.82) | 1.87 (1.59) | 3.66 (3.09) |
| Kidney infection | 94 | 5.2 (4.24) | 5.19 (26.89) | 2.36 (2.07) | 5.12 (4.32) |
| Oral herpes | 71 | 4.05 (3.21) | 4.05 (13.34) | 2 (1.67) | 4.01 (3.3) |
| Staphylococcal infection | 71 | 3.21 (2.54) | 3.21 (11.14) | 1.67 (1.34) | 3.18 (2.62) |
| Viral infection | 63 | 2.72 (2.12) | 2.72 (7.41) | 1.44 (1.09) | 2.71 (2.2) |
| Postprocedural infection | 62 | 8.47 (6.58) | 8.47 (13.96) | 3.05 (2.68) | 8.27 (6.69) |
| Tooth infection | 60 | 4.94 (3.83) | 4.94 (10.69) | 2.29 (1.93) | 4.88 (3.94) |
| Respiratory tract infection | 55 | 2.65 (2.03) | 2.65 (5.48) | 1.4 (1.03) | 2.64 (2.11) |
| Bacterial infection | 54 | 3.66 (2.8) | 3.66 (7.18) | 1.86 (1.48) | 3.63 (2.9) |
| Postoperative wound infection | 45 | 7.33 (5.46) | 7.33 (7.05) | 2.84 (2.42) | 7.18 (5.61) |
| Eye infection | 44 | 4.47 (3.32) | 4.47 (5.45) | 2.14 (1.72) | 4.42 (3.45) |
| Gastroenteritis viral | 44 | 3.52 (2.62) | 3.52 (4.63) | 1.8 (1.39) | 3.49 (2.72) |
|
| Neoplasms benign, malignant, and unspecified (including cysts and polyps) | Skin cancer | 153 | 4.88 (4.16) | 4.87 (69.02) | 2.27 (2.04) | 4.81 (4.21) |
| Basal cell carcinoma | 71 | 5.01 (3.96) | 5 (15.07) | 2.3 (1.97) | 4.94 (4.06) |
| Squamous cell carcinoma of skin | 50 | 9.54 (7.2) | 9.54 (9.35) | 3.21 (2.8) | 9.28 (7.33) |
| Malignant melanoma | 46 | 3.37 (2.52) | 3.37 (4.88) | 1.74 (1.34) | 3.34 (2.62) |
|
| Cardiac disorders | Myocardial infarction | 225 | 2.94 (2.58) | 2.94 (102.88) | 1.55 (1.36) | 2.92 (2.61) |
|
| Vascular disorders | Thrombosis | 229 | 3.35 (2.94) | 3.34 (120.29) | 1.73 (1.54) | 3.32 (2.97) |
|
| Respiratory, thoracic, and mediastinal disorders | Lung disorder | 104 | 2.59 (2.13) | 2.58 (18.98) | 1.36 (1.09) | 2.57 (2.19) |
| Chronic obstructive pulmonary disease | 99 | 2.63 (2.16) | 2.63 (17.56) | 1.39 (1.11) | 2.61 (2.21) |
| Pulmonary thrombosis | 77 | 7.09 (5.66) | 7.09 (20.42) | 2.8 (2.47) | 6.95 (5.75) |
| Pulmonary fibrosis | 63 | 4.47 (3.49) | 4.47 (11.17) | 2.14 (1.79) | 4.42 (3.59) |
| Respiratory disorder | 62 | 2.62 (2.04) | 2.62 (6.87) | 1.38 (1.04) | 2.61 (2.12) |
| Sinus disorder | 60 | 3.61 (2.79) | 3.6 (8.77) | 1.84 (1.48) | 3.57 (2.89) |
|
| Metabolism and nutrition disorders | Hypophagia | 55 | 2.83 (2.17) | 2.82 (5.89) | 1.49 (1.12) | 2.81 (2.25) |
|
| Nervous system disorders | Cerebrovascular accident | 251 | 2.46 (2.17) | 2.46 (103.55) | 1.29 (1.11) | 2.45 (2.2) |
| Carpal tunnel syndrome | 107 | 9.48 (7.82) | 9.47 (42.75) | 3.2 (2.93) | 9.22 (7.85) |
| Sciatica | 83 | 6.58 (5.29) | 6.57 (23.12) | 2.69 (2.38) | 6.46 (5.38) |
| Dysstasia | 76 | 3.2 (2.55) | 3.2 (12.73) | 1.67 (1.35) | 3.17 (2.63) |
| Nerve compression | 70 | 9.17 (7.23) | 9.16 (18.15) | 3.16 (2.81) | 8.93 (7.32) |
| Transient ischaemic attack | 56 | 3.1 (2.38) | 3.09 (6.71) | 1.62 (1.25) | 3.07 (2.47) |
|
| Skin and subcutaneous tissue disorders | Acne | 393 | 3.45 (3.12) | 3.44 (362.94) | 1.77 (1.63) | 3.41 (3.14) |
| Dermatitis atopic | 125 | 3.41 (2.86) | 3.41 (36.41) | 1.76 (1.51) | 3.38 (2.92) |
| Skin disorder | 120 | 4.18 (3.49) | 4.18 (38.89) | 2.05 (1.79) | 4.13 (3.55) |
| Eczema | 94 | 2.67 (2.18) | 2.66 (16.09) | 1.41 (1.12) | 2.65 (2.23) |
| Skin ulcer | 55 | 2.55 (1.96) | 2.55 (5.22) | 1.34 (0.98) | 2.54 (2.03) |
|
| Hepatobiliary disorders | Cholelithiasis | 48 | 2.63 (1.98) | 2.63 (4.13) | 1.39 (0.99) | 2.62 (2.06) |
|
| Renal and urinary disorders | Nephrolithiasis | 136 | 3.37 (2.85) | 3.37 (42.68) | 1.74 (1.5) | 3.34 (2.9) |
|
| Eye disorders | Cataract | 325 | 6.62 (5.93) | 6.59 (355.04) | 2.7 (2.54) | 6.48 (5.91) |
|
| Gastrointestinal disorders | Gastric disorder | 110 | 3.15 (2.61) | 3.15 (26.33) | 1.65 (1.38) | 3.13 (2.67) |
|
| General disorders and administration site conditions | Pain | 2048 | 3.09 (2.96) | 3.03 (8864.88) | 1.59 (1.52) | 3.01 (2.9) |
| Peripheral swelling | 630 | 3.79 (3.5) | 3.76 (1001.38) | 1.9 (1.79) | 3.73 (3.49) |
| Illness | 467 | 3.7 (3.38) | 3.68 (541.4) | 1.87 (1.74) | 3.65 (3.38) |
| Gait disturbance | 368 | 2.46 (2.22) | 2.45 (221.91) | 1.29 (1.14) | 2.44 (2.24) |
| Unevaluable event | 283 | 4.56 (4.06) | 4.55 (227.7) | 2.17 (2) | 4.5 (4.08) |
| Inflammation | 263 | 5.33 (4.72) | 5.32 (212.95) | 2.39 (2.22) | 5.24 (4.73) |
| Swelling | 233 | 2.62 (2.3) | 2.61 (96.57) | 1.38 (1.19) | 2.6 (2.33) |
| Gait inability | 186 | 4.39 (3.79) | 4.38 (96.18) | 2.11 (1.91) | 4.33 (3.84) |
| Impaired healing | 95 | 3.99 (3.26) | 3.99 (23.65) | 1.98 (1.7) | 3.95 (3.33) |
| Hernia | 72 | 4.37 (3.46) | 4.36 (14.38) | 2.11 (1.78) | 4.32 (3.55) |
| Nodule | 61 | 5.44 (4.22) | 5.44 (11.57) | 2.42 (2.06) | 5.36 (4.34) |
| Cyst | 54 | 5.18 (3.96) | 5.18 (8.86) | 2.35 (1.97) | 5.11 (4.08) |
|
| Immune system disorders | Immunodeficiency | 62 | 4.05 (3.15) | 4.05 (10.18) | 2 (1.65) | 4.01 (3.25) |
|
| Injury, poisoning, and procedural complications | Fall | 839 | 3.23 (3.02) | 3.2 (1560.17) | 1.67 (1.57) | 3.18 (3) |
| Procedural pain | 122 | 6.23 (5.2) | 6.22 (48.93) | 2.61 (2.36) | 6.11 (5.26) |
| Hip fracture | 118 | 4.72 (3.94) | 4.72 (40.36) | 2.22 (1.96) | 4.66 (4) |
| Postprocedural complication | 106 | 9.16 (7.55) | 9.15 (41.61) | 3.16 (2.88) | 8.91 (7.58) |
| Upper limb fracture | 91 | 5.27 (4.28) | 5.26 (25.36) | 2.38 (2.08) | 5.19 (4.36) |
| Road traffic accident | 86 | 2.92 (2.36) | 2.92 (14.92) | 1.54 (1.24) | 2.9 (2.43) |
| Spinal fracture | 84 | 5.03 (4.05) | 5.02 (21.13) | 2.31 (2) | 4.96 (4.14) |
| Limb injury | 82 | 3.1 (2.49) | 3.09 (14.38) | 1.62 (1.31) | 3.07 (2.56) |
| Joint injury | 81 | 4.44 (3.56) | 4.44 (18.38) | 2.13 (1.82) | 4.39 (3.65) |
| Ankle fracture | 80 | 6.29 (5.04) | 6.28 (21.12) | 2.63 (2.31) | 6.18 (5.13) |
| Femur fracture | 76 | 4.25 (3.39) | 4.24 (15.76) | 2.07 (1.75) | 4.2 (3.48) |
| Lower limb fracture | 74 | 5.02 (3.99) | 5.02 (16.39) | 2.31 (1.98) | 4.95 (4.09) |
| Tendon rupture | 70 | 9.82 (7.74) | 9.81 (18.45) | 3.25 (2.91) | 9.54 (7.82) |
| Head injury | 66 | 2.86 (2.24) | 2.85 (8.58) | 1.5 (1.17) | 2.84 (2.32) |
| Rib fracture | 63 | 3.63 (2.83) | 3.62 (9.71) | 1.85 (1.5) | 3.59 (2.92) |
| Foot fracture | 62 | 3.77 (2.94) | 3.77 (9.69) | 1.9 (1.55) | 3.74 (3.03) |
| Meniscus injury | 59 | 10.38 (8.01) | 10.37 (13.27) | 3.33 (2.95) | 10.07 (8.1) |
| Joint dislocation | 58 | 7.23 (5.57) | 7.22 (11.66) | 2.82 (2.45) | 7.08 (5.7) |
| Wrist fracture | 45 | 4.57 (3.41) | 4.57 (5.77) | 2.18 (1.76) | 4.52 (3.53) |
| Muscle strain | 43 | 5.99 (4.43) | 5.98 (5.99) | 2.56 (2.13) | 5.89 (4.57) |
| Ligament sprain | 41 | 4.58 (3.36) | 4.57 (4.79) | 2.18 (1.74) | 4.52 (3.49) |
| Pelvic fracture | 40 | 6.94 (5.08) | 6.94 (5.47) | 2.77 (2.31) | 6.81 (5.24) |
| Back injury | 38 | 4.69 (3.41) | 4.69 (4.17) | 2.21 (1.76) | 4.64 (3.55) |
|
| Investigations | Blood cholesterol increased | 246 | 8.3 (7.31) | 8.27 (218.4) | 3.02 (2.83) | 8.09 (7.27) |
| SARS-CoV-2 test positive | 185 | 6.14 (5.31) | 6.12 (111.88) | 2.59 (2.38) | 6.03 (5.33) |
| Hepatic enzyme increased | 170 | 2.87 (2.47) | 2.86 (57.18) | 1.51 (1.29) | 2.85 (2.51) |
| Grip strength decreased | 122 | 16.08 (13.4) | 16.05 (61.09) | 3.94 (3.67) | 15.32 (13.15) |
| Inflammatory marker increased | 59 | 11.26 (8.68) | 11.25 (13.49) | 3.44 (3.06) | 10.89 (8.76) |
| Product residue present | 46 | 5.83 (4.36) | 5.83 (6.78) | 2.52 (2.1) | 5.74 (4.5) |
|
| Musculoskeletal and connective tissue disorders | Arthralgia | 1719 | 4.87 (4.64) | 4.77 (8660.33) | 2.24 (2.17) | 4.71 (4.52) |
| Rheumatoid arthritis | 1318 | 11.03 (10.44) | 10.83 (6692.69) | 3.39 (3.31) | 10.5 (10.03) |
| Pain in extremity | 1230 | 5.47 (5.16) | 5.38 (4697.75) | 2.41 (2.33) | 5.31 (5.06) |
| Musculoskeletal stiffness | 650 | 8.04 (7.44) | 7.97 (1510.13) | 2.96 (2.85) | 7.8 (7.3) |
| Back pain | 577 | 3.24 (2.98) | 3.22 (740.3) | 1.68 (1.56) | 3.2 (2.98) |
| Joint swelling | 456 | 3.8 (3.46) | 3.78 (525.91) | 1.91 (1.77) | 3.75 (3.47) |
| Mobility decreased | 390 | 6.38 (5.77) | 6.35 (504.31) | 2.64 (2.5) | 6.24 (5.74) |
| Arthritis | 325 | 4.63 (4.15) | 4.61 (302.66) | 2.19 (2.03) | 4.56 (4.16) |
| Osteoarthritis | 297 | 8.46 (7.54) | 8.43 (319.97) | 3.04 (2.88) | 8.23 (7.47) |
| Arthropathy | 257 | 4.45 (3.93) | 4.43 (185.09) | 2.13 (1.96) | 4.39 (3.96) |
| Joint range of motion decreased | 231 | 22.41 (19.61) | 22.34 (227.29) | 4.39 (4.19) | 20.91 (18.7) |
| Musculoskeletal disorder | 197 | 12.51 (10.84) | 12.47 (153.29) | 3.59 (3.38) | 12.03 (10.68) |
| Joint stiffness | 156 | 7.24 (6.18) | 7.23 (84.36) | 2.83 (2.6) | 7.09 (6.2) |
| Intervertebral disc protrusion | 142 | 9.11 (7.7) | 9.09 (74.56) | 3.15 (2.91) | 8.86 (7.7) |
| Systemic lupus erythematosus | 142 | 3.83 (3.25) | 3.83 (51.38) | 1.92 (1.69) | 3.79 (3.3) |
| Neck pain | 139 | 3.2 (2.7) | 3.19 (42.55) | 1.66 (1.43) | 3.17 (2.76) |
| Psoriatic arthropathy | 105 | 2.53 (2.09) | 2.53 (18.79) | 1.33 (1.06) | 2.51 (2.14) |
| Rotator cuff syndrome | 87 | 9.91 (8.01) | 9.9 (28.56) | 3.27 (2.96) | 9.63 (8.05) |
| Back disorder | 83 | 6.43 (5.17) | 6.42 (22.93) | 2.66 (2.35) | 6.31 (5.26) |
| Fibromyalgia | 81 | 4.03 (3.23) | 4.02 (17.3) | 1.99 (1.69) | 3.98 (3.32) |
| Foot deformity | 80 | 7.75 (6.21) | 7.75 (22.66) | 2.92 (2.6) | 7.58 (6.3) |
| Exostosis | 54 | 8.77 (6.69) | 8.77 (10.68) | 3.1 (2.7) | 8.55 (6.82) |
| Spinal stenosis | 52 | 7.38 (5.61) | 7.38 (9.43) | 2.85 (2.46) | 7.23 (5.74) |
| Finger deformity | 47 | 11.59 (8.66) | 11.59 (8.61) | 3.49 (3.05) | 11.21 (8.78) |
| Intervertebral disc degeneration | 47 | 6.66 (4.99) | 6.65 (7.44) | 2.71 (2.29) | 6.53 (5.13) |
| Trigger finger | 44 | 12.36 (9.14) | 12.35 (7.63) | 3.58 (3.12) | 11.92 (9.26) |
| Joint noise | 34 | 12.09 (8.59) | 12.09 (4.54) | 3.55 (3.02) | 11.67 (8.76) |
| Joint lock | 32 | 15.76 (11.05) | 15.75 (4.19) | 3.91 (3.34) | 15.04 (11.17) |
|
| Social circumstances | Loss of personal independence in daily activities | 318 | 4.53 (4.05) | 4.51 (286.19) | 2.16 (2) | 4.46 (4.06) |
| Bedridden | 47 | 4.86 (3.64) | 4.85 (6.5) | 2.26 (1.85) | 4.79 (3.77) |
| Walking aid user | 41 | 9.39 (6.88) | 9.39 (6.26) | 3.19 (2.73) | 9.14 (7.05) |
| Surgical and medical procedures | Therapy interrupted | 644 | 7.92 (7.32) | 7.85 (1476.08) | 2.94 (2.83) | 7.69 (7.2) |
| Surgery | 627 | 13.87 (12.8) | 13.75 (1578.74) | 3.72 (3.61) | 13.21 (12.35) |
| Knee arthroplasty | 400 | 24.85 (22.44) | 24.71 (687.74) | 4.52 (4.38) | 22.97 (21.08) |
| Spinal operation | 302 | 25.47 (22.64) | 25.36 (392.85) | 4.56 (4.39) | 23.52 (21.32) |
| Hip arthroplasty | 207 | 16.29 (14.17) | 16.25 (176.16) | 3.95 (3.75) | 15.49 (13.78) |
| Knee operation | 202 | 26.83 (23.23) | 26.75 (176.5) | 4.63 (4.42) | 24.71 (21.91) |
| Foot operation | 99 | 27.22 (22.16) | 27.18 (42.44) | 4.65 (4.34) | 25.08 (21.12) |
| Limb operation | 99 | 26.8 (21.82) | 26.76 (42.39) | 4.63 (4.32) | 24.72 (20.81) |
| Shoulder operation | 86 | 26.16 (20.99) | 26.13 (31.93) | 4.6 (4.26) | 24.18 (20.11) |
| Hip surgery | 82 | 18 (14.4) | 17.98 (27.99) | 4.09 (3.76) | 17.05 (14.15) |
| Shoulder arthroplasty | 74 | 36.24 (28.48) | 36.2 (24.17) | 5.02 (4.64) | 32.53 (26.59) |
| Spinal fusion surgery | 58 | 20.29 (15.56) | 20.27 (14.19) | 4.26 (3.84) | 19.09 (15.29) |
| Neck surgery | 53 | 25.46 (19.24) | 25.44 (12.1) | 4.56 (4.11) | 23.6 (18.67) |
| Eye operation | 50 | 13.62 (10.26) | 13.61 (10.02) | 3.71 (3.28) | 13.08 (10.32) |
| Hysterectomy | 44 | 8.18 (6.06) | 8.18 (6.96) | 3 (2.56) | 7.99 (6.22) |
| Oral surgery | 43 | 25.74 (18.86) | 25.73 (7.97) | 4.58 (4.06) | 23.84 (18.37) |
| Joint arthroplasty | 40 | 29.79 (21.53) | 29.77 (6.97) | 4.77 (4.22) | 27.26 (20.78) |
| Cholecystectomy | 39 | 5.93 (4.32) | 5.93 (4.91) | 2.55 (2.09) | 5.84 (4.48) |
| Tooth extraction | 39 | 4.75 (3.46) | 4.75 (4.42) | 2.23 (1.78) | 4.69 (3.6) |
| Medical device implantation | 36 | 30.7 (21.8) | 30.68 (5.66) | 4.81 (4.21) | 28.02 (21.04) |
| Dental operation | 36 | 20.79 (14.83) | 20.78 (5.48) | 4.29 (3.74) | 19.54 (14.73) |
| Ankle operation | 31 | 26.88 (18.62) | 26.86 (4.16) | 4.63 (3.99) | 24.81 (18.25) |
|
