In Silico Screening, In Vitro M^pro Inhibitory, and Adjunctive Therapy Value of Minocycline for the Treatment of COVID-19

Figure 1

N3 bound in M^pro active site and the diagram of the interactions in the coco-crystal [11]. P1, P1′, P2, P3, P4, and P5 sites of N3 are indicated; 2Fo-Fc density map is shown around N3 molecule in blue mesh, C145-A in yellow mesh, and water in blue mesh. The key residue is shown in stick, hydrogen bond is shown in black dashed line, and water is shown as red sphere.