Poor Correlation of Rivaroxaban Concentration with the Routine Coagulation Screening Test in Chinese Patients with Atrial Fibrillation

Table 1

The correlation of rivaroxaban plasma concentration and routine coagulation parameters.

Parameters	Correlation	PT	INR	aPTT	TT
Ctrough	Spearman’s correlation coefficient	0.495	0.506	0.241	0.074
	Significance ( value)	<0.001	<0.001	0.009	0.431
Cpeak	Spearman’s correlation coefficient	0.023	0.027	−0.073	−0.075
	Significance ( value)	0.807	0.773	0.436	0.425
Normalized Ctrough	Spearman’s correlation coefficient	0.454	0.465	0.212	0.115
	Significance ( value)	<0.001	<0.001	0.026	0.229
Normalized Cpeak	Spearman’s correlation coefficient	0.011	0.015	−0.068	−0.075
	Significance ( value)	0.912	0.878	0.476	0.430

PT, prothrombin time; aPTT, activated partial thromboplastin time; INR, international normalized ratio; TT, thrombin time; C_trough, trough concentration; C_peak, peak concentration. Normalized concentrations were used for dose correction, thus reducing variation.