Poor Correlation of Rivaroxaban Concentration with the Routine Coagulation Screening Test in Chinese Patients with Atrial Fibrillation

Table 2

Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of routine coagulation parameters for the detection of rivaroxaban lever greater than 4 different concentrations (5, 30, 50, or 100 ng/mL).

Coagulation parameters	Performance	>5 ng/mL	>30 ng/mL	>50 ng/mL	>100 ng/mL
PT	Sensitivity	39.8 (30.4–49.9)	63.4 (46.9–77.4)	83.3 (50.9–97.1)	100.0 (46.3–100)
	Specificity	84.6 (53.7–97.3)	77.3 (65.9–85.9)	68.3 (58.3–76.9)	65.8 (56.1–74.3)
	PPV	95.3 (82.9–99.2)	60.5 (44.5–74.6)	23.3 (12.3–39.0)	11.6 (4.36–25.9)
	NPV	15.1 (8.12–25.8)	79.5 (68.1–87.7)	97.3 (89.6–99.5)	100.0 (93.8–100)
INR	Sensitivity	28.2 (20.0–38.0)	51.2 (35.4–66.8)	83.3 (50.9–97.1)	100.0 (46.3–100)
	Specificity	92.3 (62.1–99.6)	88.0 (78.0–94.0)	80.8 (71.6–87.6)	77.5 (68.4–84.6)
	PPV	96.7 (80.9–99.8)	70.0 (50.4–84.6)	33.3 (17.9–52.9)	16.7 (6.30–35.5)
	NPV	14.0 (7.72–23.5)	76.7 (66.2–84.9)	97.7 (91.1–99.6)	100.0 (94.7–100)
aPTT	Sensitivity	3.9 (1.25–10.2)	9.8 (3.17–24.1)	25.0 (6.69–57.2)	60.0 (17.0–92.7)
	Specificity	92.3 (62.1–99.6)	98.7 (91.8–99.9)	98.1 (92.5–99.7)	98.2 (93.0–99.7)
	PPV	80.0 (29.9–98.9)	80.0 (29.9–98.9)	60.0 (17.0–92.7)	60.0 (17.0–92.7)
	NPV	10.8 (5.96–18.5)	66.7 (57.0–75.2)	91.9 (84.8–96.0)	98.2 (93.0–99.7)
TT	Sensitivity	4.9 (1.80–11.5)	4.9 (0.849–17.8)	0.0 (0–30.1)	0.0 (0–53.7)
	Specificity	100.0 (71.7–100)	96.0 (88.0–99.0)	95.2 (88.6–98.2)	95.5 (89.3–98.3)
	PPV	100.0 (46.3–100)	40.0 (7.26–83.0)	0.0 (0–53.7)	0.0 (0–53.7)
	NPV	11.7 (6.63–19.5)	64.9 (55.2–73.5)	89.2 (81.5–94.0)	95.5 (89.3–98.3)

Data in parenthesis (brackets) means 95% confidence intervals (CI). The normal range of PT, INR, aPTT, and TT were 9–13 s, 0.8–1.2, 20–40 s, and 14–24 s, respectively. PPV, positive predictive value; NPV, negative predictive value; PT, prothrombin time; aPTT, activated partial thromboplastin time; INR, international normalized ratio; TT, thrombin time.