Occurrence of irAEs after Immune Checkpoint Inhibitor Rechallenge: An Updated Meta-Analysis

Figure 2

(a) Forest plot (random-effects model) of the association between ICI rechallenge and all-grade irAEs occurrence after ICI rechallenge. CI, confidence interval; ICIs, immune checkpoint inhibitors; irAEs, immune-related adverse events; M-H, Mantel–Haenszel model. The sizes of the squares indicate the weight of the study. (b) Forest plot (random-effects model) of the association between ICI rechallenge and high-grade irAE occurrence after ICI rechallenge. CI, confidence interval; ICIs, immune checkpoint inhibitors; irAEs, immune-related adverse events; M-H, Mantel–Haenszel model. The sizes of the squares indicate the weight of the study. High-grade was considered grade ≥3.

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