Research Article
Investigation of the Potential Targets and Mechanism Actions of Berberine in the Treatment of Pulpitis Based on Bioinformatics Analysis
Table 1
ADMET parameters of berberine predicted using pkCSM.
| | Property | Model name | Predicted value | Unit |
| | Absorption | Intestinal absorption (human) | 97.147 | Numeric (% absorbed) |
| | Distribution | BBB permeability | 0.198 | Numeric (log BB) |
| | Metabolism | CYP2C19 inhibitor | No | Categorical (yes/no) | | CYP2C9 inhibitor | No | Categorical (yes/no) |
| | Excretion | Total clearance | 1.27 | Numeric (log ml/min/kg) | | Renal OCT2 substrate | No | Categorical (yes/no) |
| | Toxicity | Oral rat acute toxicity (LD50) | 2.571 | Numeric (mol/kg) | | Oral rat chronic toxicity (LOAEL) | 1.89 | Numeric (log mg/kg·bw/day) | | Skin sensitisation | No | Categorical (yes/no) | | Max. tolerated dose (human) | 0.144 | Numeric (log mg/kg/day) |
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