Echinatin Inhibits Oxidative Stress and Inflammatory Processes in Trophoblast Cells by Inhibiting TLR4-MyD88-NF-κB Pathway in Preeclampsia

Figure 6

The mechanism diagram of echinatin in preeclampsia. Echinatin can enhance cell viability, reduce cell apoptosis, and decrease the expression of inflammatory factors such as IL-6, IL-18, and TNF-α. It promotes the activity of SOD and GSH-Px to inhibit inflammation while reducing the production of MDA and ROS to improve oxidative stress in H₂O₂-induced progression of preeclampsia by inhibiting the TLR4-MyD88-NF-κB signaling pathway.