Cerebrospinal Pharmacokinetic Analysis and Pharmacodynamic Evaluation of Ceftriaxone in Pediatric Patients with Bacterial Meningitis

Table 1

Summary of demographic parameters in pediatric patients with suspected bacterial meningitis.

	N = 24
	Number (%) or mean ± S.D. (range)
Sex (male: female: not applicable)	10 : 4 : 10
Age (years)	4.0 ± 4.0 (0.52–13)^a
Neonate (0–34 days)	3 (12.5%)
Infant (35 days-2 years)	7 (29.2%)
Child (2–11 years)	12 (50%)
Adolescent (12–16 years)	1 (4.2%)
Not applicable	1 (4.2%)
Body weight (kg)	14.8 ± 13.1 (3.5–50.0)^b
Dose of ceftriaxone (mg/kg)	43.2 ± 16.1 (10.0–80.0)
Single dose	8 (33.3%)
Twice daily	12 (50%)
Three times daily	4 (16.7%)
Clinical diagnosis
Bacterial meningitis	12 (50%)
Aseptic meningitis	12 (50%)

^aOne patient was excluded due to data loss; ^bten patients were excluded due to data loss.