Cerebrospinal Pharmacokinetic Analysis and Pharmacodynamic Evaluation of Ceftriaxone in Pediatric Patients with Bacterial Meningitis

Table 2

Final estimates of population pharmacokinetic parameters.

	Estimate	(RSE %)	95% CI
Fix effects parameter
CL (L/h/kg)
	0.0444	(18.0)	0.0310–0.0635
(L/kg)
	0.339	(19.1)	0.217–0.469
KPCSF
	0.0628	Fixed
(L/h/kg)
	0.000180	(49.9)	0.0000517–0.001339
(L/kg)
	0.00484	(99.3)	0.000977–0.0298
Interindividual variability (exponential error model)
ηCL	0.365	(53.4)	0.0389–0.720
	0.698	(31.4)	0.239–1.15
ηKPCSF	1.01	(52.5)	0.258–2.43
	2.31	(48.4)	0.941–5.81
	2.31	(41.1)	0.941–5.81
Residual variability (proportion error model)
	0.0310	(39.4)	0.0131–0.0656

CI, confidence interval determined from 1000 bootstrap replicates RSE, relative standard error. θ, population mean value; η, random variable which is normally distributed with a mean of zero and variance. ε, random error which is normally distributed with a mean of zero and variance.