Cerebrospinal Pharmacokinetic Analysis and Pharmacodynamic Evaluation of Ceftriaxone in Pediatric Patients with Bacterial Meningitis

Table 3

Pharmacokinetic/pharmacodynamic breakpoints of ceftriaxone in cerebrospinal fluid (CSF).

Ceftriaxone regimen	PK/PD target in CSF (100% T > MIC)
40 mg/kg q12 h 0.5 h-infusion	0.125
40 mg/kg q12 h 4 h-infusion	0.25
50 mg/kg q12 h 0.5 h-infusion	0.125
50 mg/kg q12 h 4 h-infusion	0.25
60 mg/kg q12 h 0.5 h-infusion	0.125
60 mg/kg q12 h 4 h-infusion	0.25
80 mg/kg q24 h 0.5 h-infusion	0.008
80 mg/kg q24 h 4 h-infusion	0.016
100 mg/kg q24 h 0.5 h-infusion	0.008
100 mg/kg q24 h 4 h-infusion	0.016
120 mg/kg q24 h 0.5 h-infusion	0.016
120 mg/kg q24 h 4 h-infusion	0.03

Pharmacokinetic/pharmacodynamic breakpoints are defined as the largest MIC attaining more than 90% probabilities.