Cerebrospinal Pharmacokinetic Analysis and Pharmacodynamic Evaluation of Ceftriaxone in Pediatric Patients with Bacterial Meningitis

Table 4

Expected probabilities of attaining PK/PD target (100% T > MIC) for ceftriaxone in cerebrospinal fluid (CSF), against bacterial populations (Figure 2) using different ceftriaxone regimens.

Ceftriaxone regimen	% expected probability of attaining PK/PD target (100% T > MIC) in CSF
	S. agalactiae; (MIC90 = 0.06)	S. pneumoniae; (MIC90 = 1)	N. meningitidis; (MIC90 = 0.002)	H. influenzae; (MIC90 = 0.008)	E. coli; (MIC90 = 0.06)	K. pneumoniae; (MIC90 = 0.25)
40 mg/kg q12 h; 0.5 h-infusion	94.8	92.1	98.4	97.4	94.4	93.8
40 mg/kg q12 h; 4 h-infusion	96.2	93.9	98.8	98.4	95.7	95.4
50 mg/kg q12 h; 0.5 h-infusion	95.1	92.8	98.4	97.6	94.7	94.2
50 mg/kg q12 h; 4 h-infusion	96.6	94.9	98.9	98.6	96.2	96.0
60 mg/kg q12 h; 0.5 h-infusion	95.5	93.4	98.4	97.8	95.0	94.6
60 mg/kg q12 h; 4 h-infusion	96.8	95.4	99.0	98.7	96.6	96.4
80 mg/kg q24 h; 0.5 h-infusion	85.5	82.9	93.3	91.9	85.7	84.1
80 mg/kg q24 h; 4 h-infusion	87.4	84.6	94.2	93.1	87.4	86.0
100 mg/kg q24 h; 0.5 h-infusion	86.3	84.1	93.6	92.4	86.5	85.2
100 mg/kg q24 h; 4 h-infusion	88.4	85.8	94.6	93.3	88.3	87.1
120 mg/kg q24 h; 0.5 h-infusion	87.0	84.8	94.0	92.5	87.1	85.8
120 mg/kg q24 h; 4 h-infusion	88.9	86.6	95.0	93.7	88.9	87.8