Gender Differences in Adverse Events of Ketamine Drugs: A Real-World Study Based on FAERS

Table 2

Detection results of gender difference risk signals for ketamine.

SOC	HLGT	PT	Male	Female	ROR (95% CI)	PRR (95% CI)
Psychiatric disorders	Various dissociative disorders	Dissociation	398	221	1.32 (1.11, 1.56)	1.32 (1.11, 1.56)
	Various acts of suicide and self-harm (not classified)	Suicidal ideation	202	113	1.30 (1.03, 1.64)	1.30 (1.03, 1.64)
	Depressive mood disorders and confusion	Depression	142	84	1.22 (1.13, 1.61)	1.22 (1.13, 1.61)
	Anxiety disorders and symptoms	Anxiety	130	64	1.48 (1.09, 1.99)	1.48 (1.09, 1.99)
	Various acts of suicide and self-harm (not classified)	Suicide attempt	72	41	1.27 (0.86, 1.87)	1.27 (0.86, 1.87)
Nervous system disorders	Neurological diseases (not otherwise classified)	Sedation	294	165	1.30 (1.07, 1.58)	1.30 (1.07, 1.58)
	Neurological diseases (not otherwise classified)	Dizziness	113	78	2.25 (1.78, 2.90)	2.25 (1.78, 2.90)
	Headache of all kinds	Headache	75	24	2.27 (1.43, 3.60)	2.27 (1.43, 3.60)
	Neurological diseases (not otherwise classified)	Somnolence	43	26	1.19 (0.73, 1.95)	1.19 (0.73, 1.95)
Vomiting	Signs and symptoms of gastrointestinal system	Nausea	162	86	1.37 (1.05, 1.78)	1.37 (1.05, 1.78)
	Signs and symptoms of gastrointestinal system	Vomiting	136	78	1.26 (0.95, 1.67)	1.26 (0.95, 1.67)
	Signs and symptoms of gastrointestinal system	Abdominal pain upper	19	4	3.43 (1.17, 10.10)	3.43 (1.17, 10.10)
	Oral soft tissue diseases	Hypoaesthesia oral	12	5	1.73 (0.61, 4.92)	1.73 (0.61, 4.92)
Inappropriate schedule of product administration	Off-specification use and intentional misuse/use of products	Off-label use	86	85	0.73 (0.54, 0.98)	0.73 (0.54, 0.98)
	Medication errors and other product use errors and problems	Product dose omission issue	83	29	2.08 (1.36, 3.18)	2.08 (1.36, 3.18)
	Various injuries (not otherwise classified)	Fall	23	10	1.66 (0.79, 3.50)	1.66 (0.79, 3.50)
	Medication errors and other product use errors and problems	Product dose omission issue	23	18	0.92 (0.50, 1.71)	0.92 (0.50, 1.71)
	Overdose and underdose (not classified separately)	Underdose	23	11	1.51 (0.74, 3.10)	1.51 (0.74, 3.10)
Hypotension	Vascular hypertensive disease	Hypotension	92	55	1.21 (0.86, 1.69)	1.21 (0.86, 1.69)
	Decreased blood pressure and abnormal blood pressure of unknown nature and shock	Hypotension	22	22	0.72 (0.40, 1.30)	0.72 (0.40, 1.30)