Population Pharmacokinetic Analysis of Selumetinib and Its N-desmethyl Metabolite in Japanese and Non-Japanese Pediatric Patients with Neurofibromatosis Type 1 and Inoperable Plexiform Neurofibromas

<div>PopPK model structure. CL: selumetinib clearance of central compartment; CLm: N-desmethyl selumetinib clearance; D1: time of zero-order absorption; F1: absolute bioavailability; Fm: fraction metabolized; Ka: first-order absorption rate constant; PopPK: population pharmacokinetic; Q: selumetinib intercompartmental clearance; V2: selumetinib volume of distribution of central compartment; V3: selumetinib volume of distribution of peripheral compartment; and V4: N-desmethyl selumetinib volume of distribution.</div>

Journal of Clinical Pharmacy and Therapeutics

fig1

Figure 1

Figure 1: Population Pharmacokinetic Analysis of Selumetinib and Its N-desmethyl Metabolite in Japanese and Non-Japanese Pediatric Patients with Neurofibromatosis Type 1 and Inoperable Plexiform Neurofibromas 

Figure 1 | Population Pharmacokinetic Analysis of Selumetinib and Its N-desmethyl Metabolite in Japanese and Non-Japanese Pediatric Patients with Neurofibromatosis Type 1 and Inoperable Plexiform Neurofibromas 