Population Pharmacokinetic Analysis of Selumetinib and Its N-desmethyl Metabolite in Japanese and Non-Japanese Pediatric Patients with Neurofibromatosis Type 1 and Inoperable Plexiform Neurofibromas

Figure 2

pcVPC for the PopPK final model. Blue shaded area: 90% CI around the predicted median; light blue shaded area: 90% CI around the 5% and 95% prediction intervals; black solid line: median of the observations; black dotted line: 5% and 95% percentiles of the observations; open circles: the observations. CI: confidence interval; DV: dependent variable; pcVPC: prediction-corrected visual predictive check; and PopPK: population pharmacokinetic.