Population Pharmacokinetic Analysis of Selumetinib and Its N-desmethyl Metabolite in Japanese and Non-Japanese Pediatric Patients with Neurofibromatosis Type 1 and Inoperable Plexiform Neurofibromas

Figure 3

Covariate impact on PopPK parameters. The grey-shaded area represents a covariate impact of 0.8–1.25-fold. The boxplots represent the uncertainty distributions of the parameters estimated for the typical individual (grey) or the uncertainty distributions of the impact of a certain covariate on an otherwise typical pediatric individual (BSA: 1.06 m²). All values are divided by the point estimate for the typical pediatric individual. BSA: body surface area; CL: selumetinib clearance of central compartment; CLm: N-desmethyl selumetinib clearance; and V2: selumetinib volume of distribution of central compartment.