Effects of Triazole Antifungal Agents on the Plasma Concentration and Dosage of Cyclosporin in Patients with Aplastic Anaemia

Table 3

Effect of co-administration with triazole antifungal agent drugs on the dose of CsA.

Time	FCZ group		POS group
	D (mg/kg/d)	ΔD (mg/kg/d)	D (mg/kg/d)	ΔD (mg/kg/d)
Without azole co-medication	3.50 ± 1.21		3.38 ± 0.96
With azole co-medication (total)	3.39 ± 0.94	0.09 ± 1.13	2.99 ± 0.49	0.40 ± 0.70
With azole co-medication (1–7 d)	3.19 ± 0.66	0.04 ± 0.53	3.07 ± 0.54	0.32 ± 0.56
With azole co-medication (8–21 d)	3.45 ± 1.13	0.06 ± 1.39	2.87 ± 0.54	1.10 ± 1.06

ΔD = D_{CsA monotherapy} − D_{time of co-administration of triazole antifungal agents}.