Research Article
Pharmacokinetics and Bioequivalence of Two Combination Metformin/Glipizide Tablets under Fasting and Fed Conditions in Chinese Healthy Subjects: A Randomized, Open-Label, Crossover Study
Table 2
Main pharmacokinetic parameters of metformin and glipizide after a single dose of the test drug or reference drug under fasting and fed conditions.
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N, number of subjects; , maximum observed drug concentration in the plasma; , the time to attain following dose; t1/2, terminal half-life of the analyte in the plasma; AUC0-t, area under the plasma concentration-time curve from time 0 to the last sampling time; AUC0-∞, area under the plasma concentration-time curve from time 0 to infinity. aOne subject withdrew from the period 2 without taking the test drug. bOne subject withdrew from the period 2 without taking the test drug. c (hour) is expressed as median (minimum, maximum). |