Pharmacokinetics and Bioequivalence of Two Combination Metformin/Glipizide Tablets under Fasting and Fed Conditions in Chinese Healthy Subjects: A Randomized, Open-Label, Crossover Study

Table 3

Bioequivalence analysis of metformin and glipizide after a single dose of the test drug or reference drug under fasting and fed.

Parameters	Fasting			Fed
	Test/Reference (%)	Intra-CV (%)	90%CI of ratio (%)	Test/Reference (%)	Intra-CV (%)	90%CI of ratio (%)
Metformin
(ng/mL)	97.9	13.0	91.7∼104.5	96.8	11.8	91.2∼102.7
AUC0-t (h  ng/mL)	96.6	10.1	91.8∼101.7	97.5	10.9	92.2∼103.0
AUC0-∞ (h  ng/mL)	98.2	8.9	93.8∼102.8	97.5	10.5	92.5∼102.8
Glipizide
(ng/mL)	115.7	12.4	108.7∼123.2	94.3	20.8	85.0∼104.6
AUC0-t (h  ng/mL)	101.4	6.8	98.0∼105.0	99.6	7.0	96.1∼103.2
AUC0-∞ (h  ng/mL)	101.4	7.2	97.7∼105.3	99.5	7.6	95.8∼103.5

CV%, within-subject coefficient of variation; , maximum observed drug concentration in the plasma; AUC_0-t, area under the plasma concentration-time curve from time 0 to the last sampling time; AUC_0-∞, area under the plasma concentration-time curve from time 0 to infinity.