Phlorizin Prevents Glomerular Hyperfiltration but not Hypertrophy in Diabetic Rats

Table 1

Body and kidney weights, blood and urinary changes in Fischer rats at one-week diabetes. Bw${\text{t}}_0=$ Initial body weight, Bw${\text{t}}_f=$ final body weight, BG = blood glucose, $V=$ urine flow rate measured over 24 hours from rats placed in metabolic cages, PER = protein excretion rate, Wt = weight, $\text{C}=$ control, $\text{D}=$ diabetic, DPLZ = phlorizin-treated diabetic, CPLZ = phlorizin-treated controls. Results are expressed as mean ± SE and compared using unpaired two-tailed student's t-test.

	Bw${\text{t}}_0$	Bw${\text{t}}_f$	BG	$V$	PER	Kidney wet	Kidney dry
	(g)	(g)	(mM/l)	(ml/24hrs)	(mg/24hrs)	wt/Bw${\text{t}}_0$%	wt/Bw${\text{t}}_0$%
C	$196.5\pm 3.2$	$208\pm 6.5$	$5.6\pm 0.3$	$6.5\pm 1.04$	$8.2\pm 1.5$	$0.39\pm 0.01$	$0.085\pm 0.003$
$n=14$
D	$192\pm 2.0$	$177.8\pm {4.9}^{**}$	$27.7\pm {1.4}^{\#\#}$	$63.4\pm {6.4}^{\#\#}$	$23.2\pm {5.6}^{\#}$	$0.43\pm {0.01}^{\#}$	$0.095\pm {0.001}^{\#}$
$n=15$
DPLZ	$199.6\pm 4.2$	$175.7\pm {2.6}^{**}$	$5.9\pm 1.1$	$47.5\pm 4^{\#\#}$	$14.3\pm {2.6}^{\#}$	$0.39\pm 0.02$	$0.078\pm 0.005$
$n=9$
CPLZ	$200\pm 2.7$	$187.6\pm {4.2}^{*\phi }$	$5.1\pm 0.2$	$21.3\pm {2.6}^{\#\#\phi \phi \phi }$	$14\pm {1.8}^{\#}$	$0.4\pm 0.02$	$0.082\pm 0.004$
$n=5$

${}^{*}=P<.05$, ${}^{**}=P<.001$ compared to initial weight using paired two-tailed student's t-test. ${}^{\#}=P<.05$, ${}^{\#\#}=P<.001$ compared to control, ${}^{\phi }=P<.05$, ${}^{\phi \phi \phi }=P<.001$ CPLZ versus DPLZ.