Radioiodinated Naphthylalanine Derivatives Targeting Pancreatic Beta Cells in Normal and Nonobese Diabetic Mice

Figure 3

Autoradiographic images of mice pancreas injected with [¹²⁵I]-IPC-β-AL3 and sacrificed 60 minutes post injection. (a) and (b) = CBA/J normal mice, (c) and (d) = 17-week-old, and (e) = 26-week-old NOD mice injected with the same quantity of radioactivity. Note the intense and scattered radioactivity in the CBA/J mice. Ex vivo autoradiograms of pancreata from normal (CBA/J) and diabetic (NOD) mice (17 weeks old). The sections were 5 μm in thickness, and images were from 30 minutes of exposure. (f) and (g) = CBA/J, (h) = NOD.

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