Radioiodinated Naphthylalanine Derivatives Targeting Pancreatic Beta Cells in Normal and Nonobese Diabetic Mice

Table 2

Comparative biodistribution of [¹³¹I]-IPC-β-AL3 in normal CBA/J and NOD mice with age, 60 minutes post injection. Values are means ± standard deviations of % ID/g, where 𝑛≥4 per time point. The small intestine was measured with its contents. The value for the thyroid is for the whole organ (% ID/organ).

	Mouse groups by age (weeks) and strain
	5		8		16
Organ/Tissue	CBA/J	NOD	CBA/J	NOD	CBA/J	NOD
Blood	0.7±0.1	1.2±0.1	0.9±0.2	0.6±0.1	0.5±0.1	0.3±0.1
Heart	1.8±0.6	0.7±0.2	2.3±0.7	1.0±0.4	1.2±0.2	0.5±0.1
Intestine (small)	20.7±13.3	10.5±2.7	7.4±1.9^*	3.3±1.5^*	12.5±3.9	17.1±5.1
Kidney	24.6±7.9	6.5±0.6	13.2±3.3	6.5±1.6	14.4±4.3	5.3±1.1
Liver	3.9±0.6	3.3±0.8	4.4±0.4	3.6±1.4	2.7±0.6	2.1±0.4
Lung	5.8±1.6	2.3±0.3	3.6±1.0	2.3±1.0	3.4±0.7	3.8±1.6
Muscle	—	0.4±0.1	0.5±0.1	0.3±0.1	—	0.3±0.1
Pancreas	5.5±1.1	2.3±0.2	3.4±1.3	1.9±0.8	5.2±0.6	1.6±0.3
Spleen	5.2±1.1	1.7±0.5	2.8±1.1	1.8±0.8	4.4±2.1	1.1±0.3
Thyroid	0.4±0.2	—	—	—	0.2±0.1	—-

^*The intestines were measured without their contents.