Islet Specific Wnt Activation in Human Type II Diabetes
Figure 2
Expression of Wnt2b, β-catenin, cyclinD1, and
c-myc in type II diabetes. Wnt2b (red in (a), (b), (d), and (e)), β-catenin
(red in (f), (g), (i), and (j)), cyclinD1 (red in (k), (l), (n), and (o)), and c-myc
(red in (q) and (s)) are absent from islets of nondiabetic individuals (a), (b), (f), (g), (k), (l), (p) and (q), but are present in islets from type II diabetics (d), (e), (i), (j), (n), (o), (r), and (s). Islets are identified by insulin (green in (a), (d), (f), (i), (p), and (r)) or glucagon (l) and (o) and are outlined by a dashed line in (g) to better demonstrate the absence of
β-catenin. Quantitation of Wnt2b (c), β-catenin (h), and cyclinD1 (m) expression in non-diabetic () and type
II () islets: error bars = mean +/−s.e.m. *. Scale
bars = 100 m except for f.g.i.j which are 50 m.
