Identification of Compounds That Inhibit IGF-I Signaling in Hyperglycemia
Figure 4
Inhibition of IGF-I-stimulated SMC proliferation. cells were plated in each well of a 24 well plate prior to exposure to IGF-I (50 ng/mL), and the test compounds (all prepared in DMEM-H + 0.2% platelet poor plasma). 48 hours after the addition of IGF-I (50ng/mL) cell number was determined by trypan blue staining and counting. when cell in response to IGF-I is compared with the number of cells in DMEM-H alone.
