Influence of Overt Diabetes Mellitus on Cyclosporine Pharmacokinetics in a Canine Model

Table 1

Biochemical parameters in healthy and diabetic beagle dogs.

Parameter	Group	Mean ± SEM	P value
Fasting serum glucose (mmo/L)	Healthy	6.88±0.69	.0003
	Diabetic	24.7±4.63
Total cholesterol (mmo/L)	Healthy	5.28±0.36	.0279
	Diabetic	7.2±0.65
High-density lipoprotein (mmo/L)	Healthy	3.38±0.25	.8331
	Diabetic	3.31±0.28
Low-density lipoprotein (mmo/L)	Healthy	1.06±0.1	.0001
	Diabetic	4.45±0.72
Triglyceride (mmo/L)	Healthy	0.73±0.14	.5042
	Diabetic	0.96±0.23
Serum creatinine (𝜇mo/L)	Healthy	65.6±1.69	.0885
	Diabetic	54.8±5.92
Blood urea nitrogen (mmo/L)	Healthy	4.0±0.85	.6719
	Diabetic	4.3±0.66