Altered Regulation of Contraction-Induced Akt/mTOR/p70S6k Pathway Signaling in Skeletal Muscle of the Obese Zucker Rat
Figure 2
Contraction-induced p70S6k phosphorylation is altered with insulin resistance. The basal (control) and contraction-induced phosphorylation of the p70S6k in Plantaris muscles from lean (LNZ) and obese (OSXZ) Zucker rats at 0, 1, and 3 hours after contractile stimulus. p70S6k (Thr389 & Thr421/Ser424) phosphorylation was determined by immunoblotting for phosphorylation on Thr389 and Thr421/Ser424. Relative abundance represents ratio of phospho to total protein. An asterisk () indicates significant difference (P < .05) from the control animals and a dagger () indicates a significant difference (P < .05) from the corresponding time points across animal models.
