Dynamic Changes of Neuroskeletal Proteins in DRGs Underlie Impaired Axonal Maturation and Progressive Axonal Degeneration in Type 1 Diabetes
Figure 5
Expression of Cdk5 (a), total GSK-3 (b), phosphorylated GSK-3 (c) and Phosphorylated/total GSK3 (d) in control and diabetic BB/Wor-rats at 2-month, 7-month, and 10-month duration. Results are means SD (). *, **, *** versus respective control rats. Linear regression analyses of the expression of GSK-3 and relative expression of phosphorylated NFH (e) and of the expression of Cdk5 and relative phosphorylated NFM (f). Note increased expression of GSK-3 and phosphorylated NFH with duration of diabetes, whereas decreased expression of Cdk5 correlated with decreased phosphorylation of NFM with increasing diabetes duration.
