Dynamic Changes of Neuroskeletal Proteins in DRGs Underlie Impaired Axonal Maturation and Progressive Axonal Degeneration in Type 1 Diabetes

Table 2

Myelinated fiber morphometry.

	2-month control	2-month BB/Wor	4-month control	4-month BB/Wor	7-month control	7-month BB/Wor	10-month control	10-month BB/Wor
Fiber area (𝜇m^2)	30.9 ± 2.6	30.7 ± 3.3	36.2 ± 3.8	32.5 ± 3.6	41.7 ± 1.0	33.3 ± 2.3^****	38.9 ± 2.0	31.4 ± 1.5^****
Axon area (𝜇m^2)	11.7 ± 1.0	11.5 ± 1.9	15.0 ± 1.6	11.9 ± 1.4^***	18.5 ± 0.5	13.6 ± 1.4^****	16.2 ± 1.1	12.4 ± 0.8^****
Myelin area (𝜇m^2)	19.2 ± 2.0	19.2 ± 1.8	22.1 ± 2.4	20.4 ± 1.3	24.8 ± 2.1	19.7 ± 1.6^***	22.7 ± 1.7	19.0 ± 1.5^**
a/m ratio	0.613 ± 0.063	0.601 ± 0.079	0.655 ± 0.119	0.624 ± 0.084	0.750 ± 0.065	0.692 ± 0.079	0.716 ± 0.069	0.654 ± 0.071
OR (%)	49.8 ± 7.6	46.6± 4.2	49.7 ± 3.5	52.4± 3.6	61.3 ± 3.7	58.3 ± 1.8	57.9 ± 4.7	50.0 ± 5.8*
I.C.	0.955 ± 0.012	0.926 ± 0.023*	0.937 ± 0.013	0.906 ± 0.017	0.946 ± 0.005	0.900 ± 0.007^****	0.924 ± 0.011	0.895 ± 0.026*

Results are means ± SD. *𝑃<.05, ^**𝑃<.01, ^***𝑃<.005 and ^****𝑃<.001 versus respective control rats.