Dynamic Changes of Neuroskeletal Proteins in DRGs Underlie Impaired Axonal Maturation and Progressive Axonal Degeneration in Type 1 Diabetes

Table 3

Unmyelinated fiber morphometry.

	2-month control	2-month BB/Wor	4-month control	4-month BB/Wor	7-month control	7-month BB/Wor	10-month control	10-month BB/Wor
Axon number/SC (#/unit)	5.01 ± 0.81	4.47 ± 0.54	5.26 ± 0.64	4.22 ± 0.29*	5.29 ± 0.26	4.17 ± 0.11^****	5.20 ± 0.34	4.03 ± 0.26^****
Mean fiber area (𝜇m^2)	0.636 ± 0.076	0.534 ± 0.049*	0.742 ± 0.090	0.613 ± 0.042*	0.706 ± 0.072	0.531 ± 0.044^***	0.676 ± 0.056	0.487 ± 0.076^***
Denervated SC (%)	0.08 ± 0.11	0.86 ± 0.40^***	0.24 ± 0.18	0.97 ± 0.26^***	1.00 ± 0.32	2.61 ± 0.57^****	2.54 ± 0.90	4.42 ± 1.32*
Collagen pocket (%)	0.76 ± 0.35	1.95 ± 0.78*	0.62 ± 0.42	1.59 ± 0.57*	1.65 ± 0.32	3.15 ± 0.89^**	7.98 ± 0.49	11.60 ± 3.36*
Type 2 relationship (%)	2.21 ± 0.40	4.29 ± 0.91^***	1.18 ± 0.13	6.45 ± 2.00^****	3.30 ± 0.54	14.45 ± 3.02^****	6.04 ± 1.47	18.22 ± 2.36^****
Regenerating fiber (%)	0.84 ± 0.39	1.59 ± 0.32^**	0.56 ± 0.43	2.07 ± 0.36^****	1.69 ± 0.51	2.49 ± 0.46*	4.28 ± 1.24	8.56 ± 3.13*

Results are means ± SD. *𝑃<.05; ^**𝑃<.01; ^***𝑃<.005; and ^****𝑃<.001