Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats

Table 2

Resting heart rate and the effect of metipranolol after atropine administration on the heart rate in diabetic and control female rats.

Months after STZ	Resting heart rate (min^−1)		Effect of MP after ATR (min^−1)
	Control (𝑛=6)	STZ (𝑛=6)	Control (𝑛=6)	STZ (𝑛=5)
1	345 ± 8	280 ± 6*	−122 ± 7	−10 ± 8*
2	352 ± 9	252 ± 7*	−130 ± 8	−8 ± 5*
4	355 ± 7	238 ± 7*	−92 ± 5	−1 ± 5*
22	345 ± 10	309 ± 11*	−116 ± 9	−105 ± 11^#

Values are means ± SEM; STZ: streptozotocin; MP: metipranolol; ATR: atropine; *significantly different from value in control group (𝑃<0.05); ^#significantly different from STZ1 value 𝑃<0.05.