Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats: A Model of Type 2 Diabetes
Figure 2
DR ameliorates mesangial expansion and renal fibrosis in WFRs. ((a)-(A) through (D)) Representative photomicrographs of PAS-stained kidney sections from four groups of rats. Data are the results of independent experiments in each group with six rats per group. Original magnification, ×400. (b) Quantitative assessment of the mesangial matrix area in the four groups of rats. Data are means ± SD. (, # versus other groups). Treatment with DR reduced glomerular and interstitial fibrosis in WFRs. ((a)-(E) through (H), (I) through (L)) Representative photomicrographs of Masson-Trichrome staining in the four groups of rats. Data are the results of independent experiments in each group with six rats per group. Original magnification, ×400 for glomerular fibrosis and ×100 for interstitial fibrosis. (c) and (d) Quantitative assessment of fibrosis in the four groups of rats. Data are means ± SD (, # versus other groups).
