Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (<i>fa/fa</i>) Rats: A Model of Type 2 Diabetes

<table>p62/Sqptm1 accumulation and electron microscopy in the kidney. (a) Representative immunoblots of p62/sequestosome 1 (Sqptm1) in protein extracts from the kidneys from rats of each group. Actin was loaded as an internal control. Data are means ± SD (<svg height="11.225" id="M27" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.225" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>, <sup>#</sup><svg height="11.375" id="M28" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus other groups).  (b) Quantitative analysis of p62/Sqptm1expression. Data are means ± SD (<svg height="11.225" id="M29" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.225" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>, <sup>#</sup><svg height="11.375" id="M30" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus other groups). (c) Representative micrographs of proximal tubular cells from the, four groups of rats. Scale bar = 1 <i>μ</i>m (<svg height="11.125" id="M31" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.125" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>).</table>

Journal of Diabetes Research

fig7

Figure 7

Figure 7: Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (<i>fa/fa</i>) Rats: A Model of Type 2 Diabetes 

Figure 7 | Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats: A Model of Type 2 Diabetes 