Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats: A Model of Type 2 Diabetes

Table 1

Effects of DR on body weight, kidney weight, blood pressure, blood glucose, glycated-Hb, and lipid profiles in the four groups of rats.

	WLRs (𝑛=10)	WLRs + DR (𝑛=11)	WFRs (𝑛=10)	WFRs + DR (𝑛=9)
Body weight (g)	426.3 ± 31.4	264.2 ± 32.7^a	671.3 ± 70.3^a	489.8 ± 34.8^b
Kidney weight (g)	2.8 ± 0.17	1.8 ± 0.06^a	3.0 ± 0.35^a	2.23 ± 0.91^a
Systolic blood pressure (mmHg)	121.9 ± 6.8	113.0 ± 11.0	126.3 ± 15.4	120.3 ± 5.1
Fasting blood glucose (mg/dL)	96.7 ± 8.8	95.7 ± 5.6	111.1 ± 11.9^c	115.4 ± 6.1^c
Glycated-Hb (%)	3.1 ± 0.25	3.1 ± 0.17	6.1 ± 0.56^c	4.9 ± 0.9^c, d
Total cholesterol (mg/dL)	132.2 ± 14.6	88.4 ± 6.7^a	207 ± 32.3^c	164.0 ± 26.5^b
Triglyceride (mg/dL)	25.3 ± 4.9	20.5 ± 10.0	179.4 ± 93.3^c	77.4 ± 25.5^c, d

Data are means ± SD.
Data are means ± SD ^a𝑃<0.01 versus other groups, ^b𝑃<0.05 versus other groups, ^c𝑃<0.01 versus WLRs, WLRs + CR, ^d𝑃<0.05 versus WFRs.