Research Article

Rising Intracellular Zinc by Membrane Depolarization and Glucose in Insulin-Secreting Clonal HIT-T15 Beta Cells

Figure 2

Zinc transients induced by repeated KCl applications and concentration dependence. (a) Repeatable responses to three consecutive KCl (60 mM) applications in the same cells. There were 10 min intervals between stimulations. Two experiments were done with about 10 cells per experiment. (b) The intracellular zinc rises were induced by 10, 30, and 60 mM KCl applications, respectively. Experiments were done in the same cells. Each presented trace is representative of at least two different experiments.
190309.fig.002a
(a)
190309.fig.002b
(b)