Severe Maternal Hyperglycemia Exacerbates the Development of Insulin Resistance and Fatty Liver in the Offspring on High Fat Diet

Figure 5

Severe maternal hyperglycemia during gestation and lactation alters islet morphology and lipid metabolism in the offspring. (a) Histological sections of hematoxylin and eosin (H&E)-stained pancreas of CON offspring and STZ offspring under standard chow (S) or high fat diet (H) feeding. Sections were examined by light microscopy at a magnification of 200x; (b) islets areas were quantified using Image J 1.40 software. Values were means ± SEM; ^∗𝑃<0.05 versus STZ-S, ^#𝑃<0.05 versus CON-H; 𝑛=5 in each group.

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