Animal Models of Diabetes Mellitus for Islet Transplantation

Table 1

Animal models of DM.

Characters	Name	Species
Type 1 DM
Spontaneous model	NOD	Mouse
	BB	Rat
Type 2 DM
	ob/ob	Mouse
	db/db	Mouse
Obesity model	fa/fa	Rat
	Goto Kakizaki	Rat
	OLETF	Rat
Type 1 and 2 DM
Drug-induced model	Alloxan	*
	STZ	*
Pancreatic DM
Pancreatomized model	Pancreatectomy	**
Others
	Insulin knockout	Mouse
Transgenic animal model	IRS1 knockout	Mouse
	IRS2 knockout	Mouse

∗All experimental animals are available.
**All experimental animals are available but larger animals tend to be used.