Journal of Diabetes Research

Review Article

Animal Models of Diabetes Mellitus for Islet Transplantation

Dose of STZ.


Animal species	Animal strains	Dose of STZ (mg/kg body weight)	Time of injection	Solvent	Method of injection	References

	ICR	90–150	1	Citrate buffer, pH 4.5	i.p	[40, 43, 45, 48]
		70	3	Citrate buffer, pH 4.5	i.p	[58]
		130–225	1	Citrate buffer, pH 4.5	i.p	[42, 44, 46, 47]
Mice	C57BL/6	75–100	3		i.v	[59, 60]
		40–65	5	Citrate buffer, pH 4.5	i.p	[49–54]
	BALB/c	150	1	Citrate buffer, pH 4.5	i.p	[61]
		50	5		i.p	[62]

		60–85	1	Citrate buffer, pH 4.5	i.p	[60, 63–65]
	Sprague-Dawley	55–60	1		i.v	[66, 67]
		50	6	Citrate buffer, pH 4.5	i.v	[68]
Rat		50–70	1	Citrate buffer, pH 4.5 or Normal saline	i.p	[69–74]
	Wistar	40	5	Citrate buffer, pH 4.5	i.p	[75]
		50–65	1	Citrate buffer, pH 4.5	i.v	[55–57]

Dog	Beagle	30–50	1		i.v	[76–78]

Velvet Monkey	Chlorocebus aethiops	45–55	1	Normal saline	i.v	[79, 80]

Cynomolgus Monkey	Macaca fascicularis	68–150	1	Citrate buffer, pH 4.5	i.v	[41, 81, 82]

	Yucatan	125	1		i.v	[83]
	Yorkshire	50	1	Citrate buffer, pH 4.5	i.v	[84]
Pig	Landrace	125	1		i.v	[85]
	Dutch Landrace X Yorkshire X Finnish Landrace	120	1		i.v	[86]
	domestic	90	1	Normal saline	i.v	[87]