Spontaneous Periodontitis Development in Diabetic Rats Involves an Unrestricted Expression of Inflammatory Cytokines and Tissue Destructive Factors in the Absence of Major Changes in Commensal Oral Microbiota

<table>Increased number of immunoreactive cells after 9 months of diabetes induction in rats. Histological sections of periodontal tissues were submitted to immunohistochemical analyses for RAGE (a), TNF-alpha (b), IL-1beta (c), IL-6 (d), and RANKL (e) after 9 months of diabetes induction in rats. Observe the presence of immunoreactive cells in all regions of periodontium (cervical, medium, and apical regions), being not limited to the gingival area.</table>

Journal of Diabetes Research

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Figure 1: Spontaneous Periodontitis Development in Diabetic Rats Involves an Unrestricted Expression of Inflammatory Cytokines and Tissue Destructive Factors in the Absence of Major Changes in Commensal Oral Microbiota 

Figure 1 | Spontaneous Periodontitis Development in Diabetic Rats Involves an Unrestricted Expression of Inflammatory Cytokines and Tissue Destructive Factors in the Absence of Major Changes in Commensal Oral Microbiota 