Differential Changes of Aorta and Carotid Vasodilation in Type 2 Diabetic GK and OLETF Rats: Paradoxical Roles of Hyperglycemia and Insulin

Figure 5

Immunofluorescent colocalization of endothelial nitric oxide synthase (eNOS, red) and inducible NOS (iNOS, green), constitutive heme oxygenase (HO-2, green) and inducible HO (HO-1, red) in aorta (AO) from control Wistar and Goto-Kakizaki rats (GK). The endothelial layer is on the left side and perivascular layers on the right side. Bar = 20 μm. Data are presented as mean ± SEM, 𝑛=6-7. *𝑃<0.05, **𝑃<0.01 versus respective controls.