Impact of Diabetes and Hyperglycemia on Survival in Advanced Breast Cancer Patients

Table 2

Univariate and multivariate analyses according to overall survival.

Variable	Overall survival (median, months)	𝑃	HR (95% CI)	P
Age (years)			1.2	0.303
Age < 49	26	0.301	(0.8–1.9)
Age 49	26
Tumor stage				<0.001
1-2	38	<0.001	2.7 (1.7–4.4)
3-4	17
Nodes				0.091
Negative	38	0.276	0.6 (0.4–1.1)
Positive	24
Grade				0.083
1-2	39	0.004	1.5 (0.9–2.2)
3	20
Hormone receptor				0.003
Positive	37	<0.001	0.2 (0.1–0.6)
Negative	18
HER2				0.015
Positive	26	0.824	0.3 (0.1–0.8)
Negative	24
Triple-negative				0.072
Positive	15	0.005	0.4 (0.1–1.1)
Negative	31
Metastatic site				0.047
Single	38	0.018	1.6 (1.0–2.4)
Multiple	24
Type of metastases				0.042
Nonvisceral	38	0.019	1.6 (1.0–2.5)
Visceral	23
Overweight or obesity at recurrence				0.680
Yes	31	0.310	0.9 (0.6–1.4)
No	23
Diabetes at recurrence				0.709
No	26	0.227	0.9 (0.4–1.9)
Yes	18
Mean glucose >130				0.034
No	27	0.023	2.8 (1.1–7.3)
Yes	12

HR: Hazard ratio.