In Vivo Efficacy of HD0471953: A Novel GPR119 Agonist for the Treatment of Type 2 Diabetes Mellitus

Table 1

The absolute and relative values on initial body weight, final body weight, inguinal fat, and epididymal fat after administration of HD0471953 for 4 weeks. The results are mean ± SD for 7 mice in each group.

	Initial body weight (g)	Final body weight (g)	Inguinal fat (g)	Inguinal fat (%)	Epididymal fat (g)	Epididymal fat (%)
Normal	24.75±1.26	26.75±0.96	0.29±0.03	1.08±0.08	0.29±0.07	1.06±0.25
Vehicle	33.66±0.92	40.14±2.67	2.97±0.46	7.38±0.80	1.71±0.46	4.27±1.11
1953—10 mpk	33.5±1.6	39.57±2.37	3.20±0.35	8.10±1.01	1.88±0.58	4.70±1.26
1953—20 mpk	32.75±1.83	40.17±1.47	2.97±0.53	7.39±1.22	1.96±0.58	4.89±1.48
1953—50 mpk	33.625±1.41	39.5±3.42	2.78±0.14	7.06±0.33	1.98±0.63	5.00±1.50