Alginate Microencapsulation of Human Islets Does Not Increase Susceptibility to Acute Hypoxia

Table 3

Effect of hypoxia on islet secreted mediators by H/N ratios (fold increase by hypoxia).

	Encapsulated islets		Nonencapsulated islets
	Mean ± SEM	Median	Mean ± SEM	Median
IL-6	3.52±0.80^∗	2.48	28.43±24.22^∗a	4.66
IL-9	0.97±0.11	1.01	1.09±0.17	0.95
IL-12	0.88±0.07	0.93	0.69±0.09^∗#	0.71
IL-8	1.59±0.23^∗	1.39	3.19±0.79^∗#	2.11
MCP-1	1.12±0.09	0.98	1.40±0.15^∗#	1.31
VEGF	0.91±0.06	0.88	0.70±0.07^∗#	0.72

^∗𝑃<0.001–0.05 for the effect of hypoxia, ^#𝑃<0.01–0.05 for the comparison of encapsulated versus non-encapsulated islets. Data are based on 11–13 single experiments (one sample per condition), one-five experiments per donor (five donors). ^aMean ± SEM contains one outlier value. Excluding the outlier changes mean ± SEM to 5.23 ± 1.19 and median to 4.14.
H/N equals ratio of hypoxic to normoxic conditions.